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1

Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia

Wilna J. Moree, Bin-Feng Li, Said Zamani-Kord, Jinghua Yu, Timothy Coon, Charles Huang, Dragan Marinkovic, Fabio C. Tucci, Siobhan Malany, Margaret J. Bradbury, Lisa M. Hernandez, Jianyun Wen, Hua Wan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 688 KB

english, 2010

2

Synthesis of peptides containing a sulfinamide or a sulfonamide transition-state isostere

Wilna J. Moree, Liesbeth C. van Gent, Gijs A. van der Marel, Rob M.J. Liskamp

Journal:

Year:

1993

Language:

english

File:

PDF, 1.59 MB

english, 1993

3

Synthesis of peptides containing the β-substituted aminoethane sulfinamide or sulfonamide transition-state isostere derived from amino acids

Wilna J. Moree, Gijs A. van der Marel, Rob M.J. Liskamp

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 267 KB

english, 1992

4

Synthesis of Peptidosulfinamides and Peptidosulfonamides: Peptidomimetics Containing the Sulfinamide or Sulfonamide Transition-State Isostere

Moree, Wilna J., van der Marel, Gijs A., Liskamp, Rob J.

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 1.84 MB

english, 1995

5

Synthese von Fucopeptiden als Sialyl-Lewisx-Mimetica

Prof. Dr. Shih-Hsiung Wu, Dr. Makoto Shimazaki, Dipl.-Chem. Chun-Cheng Lin, Dr. Lei Qiao, Dr. Wilna J. Moree, Dr. Gabriele Weitz-Schmidt, Prof. Dr. Chi-Huey Wong

Journal:

Angewandte Chemie

Year:

1996

File:

PDF, 364 KB

1996

6

Synthese neuartiger 6-Amido-6-desoxy-L-galactose-Derivate als potente Sialyl-Lewisx-Mimetica

Dr. Michael W. Cappi, Dr. Wilna J. Moree, Dr. Lei Qiao, Dr. Thomas G. Marron, Dr. Gabriele Weitz-Schmidt, Prof. Chi-Huey Wong

Journal:

Angewandte Chemie

Year:

1996

Language:

german

File:

PDF, 389 KB

german, 1996

7

Synthesis of Fucopeptides as Sialyl Lewisx Mimetics

Prof. Dr. Shih-Hsiung Wu, Dr. Makoto Shimazaki, Dipl.-Chem. Chun-Cheng Lin, Dr. Lei Qiao, Dr. Wilna J. Moree, Gabriele Weitz-Schmidt, Prof. Dr. Chi-Huey Wong

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 353 KB

english, 1996

8

The Synthesis of Novel 6-Amido-6-Deoxy-L-Galactose Derivatives as Potent Sialyl Lewisx Mimetics

Dr. Michael W. Cappi, Dr. Wilna J. Moree, Dr. Lei Qiao, Dr. Thomas G. Marron, Dr. Gabriele Weitz-Schmidt, Prof. Chi-Huey Wong

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 403 KB

english, 1996

9

ChemInform Abstract: Identification of a Novel Selective H1-Antihistamine (I) with Optimized Pharmacokinetic Properties for Clinical Evaluation in the Treatment of Insomnia.

Wilna J. Moree, et al. et al.

Journal:

Year:

2011

File:

PDF, 21 KB

2011

10

Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives

Shuichi Takayama, Wilna J. Moree, Chi-Huey Wong

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 237 KB

english, 1996

11

Brain-penetrating 2-aminobenzimidazole H1-antihistamines for the treatment of insomnia

Timothy Coon, Wilna J. Moree, Binfeng Li, Jinghua Yu, Said Zamani-Kord, Siobhan Malany, Mark A. Santos, Lisa M. Hernandez, Robert E. Petroski, Aixia Sun, Jenny Wen, Sue Sullivan, Jason Haelewyn, Micha

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.21 MB

english, 2009

12

Molecular diversity of peptidomimetics: Approaches to the solid-phase synthesis of peptidosulfonamides

Dries B.A. de Bont, Wilna J. Moree, Rob M.J. Liskamp

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 583 KB

english, 1996

13

Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series

Wilna J. Moree, Ken-ichiro Kataoka, Michele M. Ramirez-Weinhouse, Tatsuki Shiota, Minoru Imai, Takaharu Tsutsumi, Masaki Sudo, Noriaki Endo, Yumiko Muroga, Takahiko Hada, Dewey Fanning, John Saunders,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 149 KB

english, 2008

14

Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors

Wilna J. Moree, Phyllis Goldman, Anthony J. Demaggio, Erik Christenson, Dan Herendeen, John Eksterowicz, Edward A. Kesicki, David L. McElligott, Graham Beaton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 312 KB

english, 2008

15

Novel benzothiophene H1-antihistamines for the treatment of insomnia

Wilna J. Moree, Florence Jovic, Timothy Coon, Jinghua Yu, Bin-Feng Li, Fabio C. Tucci, Dragan Marinkovic, Raymond S. Gross, Siobhan Malany, Margaret J. Bradbury, Lisa M. Hernandez, Zhihong O’Brien, Ji

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 455 KB

english, 2010

16

Selectivity profiling of novel indene H1-antihistamines for the treatment of insomnia

Bin-Feng Li, Wilna J. Moree, Jinghua Yu, Timothy Coon, Said Zamani-Kord, Siobhan Malany, Kayvon Jalali, Jianyun Wen, Hua Wang, Chun Yang, Samuel R.J. Hoare, Robert E. Petroski, Ajay Madan, Paul D. Cro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 732 KB

english, 2010

17

The discovery and structure–activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia

Karine Lavrador-Erb, Satheesh Babu Ravula, Jinghua Yu, Said Zamani-Kord, Wilna J. Moree, Robert E. Petroski, Jianyun Wen, Siobhan Malany, Samuel R.J. Hoare, Ajay Madan, Paul D. Crowe, Graham Beaton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 710 KB

english, 2010

18

Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6

Charles Huang, Wilna J. Moree, Said Zamani-Kord, Bin-Feng Li, Fabio C. Tucci, Siobhan Malany, Jianyun Wen, Hua Wang, Samuel R.J. Hoare, Chun Yang, Ajay Madan, Paul D. Crowe, Graham Beaton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 930 KB

english, 2011

19

Synthesis of novel 6-amido-6-deoxy-l-galactose derivatives as sialyl Lewis X mimetics

Michael W. Cappi, Wilna J. Moree, Lei Qiao, Thomas G. Marron, Gabriele Weitz-Schmidt, Chi-Huey Wong

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 1.28 MB

english, 1997

20

Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure–activity relationships of diamine derivatives

Wilna J. Moree, Ken-ichiro Kataoka, Michele M. Ramirez-Weinhouse, Tatsuki Shiota, Minoru Imai, Masaki Sudo, Takaharu Tsutsumi, Noriaki Endo, Yumiko Muroga, Takahiko Hada, Hiroko Tanaka, Takuya Morita,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

21

Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives

Minoru Imai, Tatsuki Shiota, Ken-ichiro Kataoka, Christine M. Tarby, Wilna J. Moree, Takaharu Tsutsumi, Masaki Sudo, Michele M. Ramirez-Weinhouse, Daniel Comer, Chung-Ming Sun, Shinsuke Yamagami, Hiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

22

Peptides containing the novel methylphosphinamide transition-state isostere

Wilna J. Moree, Gijs A. van der Marel, Jacques H. van Boom, Rob M.J. Liskamp

Journal:

Year:

1993

Language:

english

File:

PDF, 903 KB

english, 1993

23

Exploitation of Subtilisin BPN‘ as Catalyst for the Synthesis of Peptides Containing Noncoded Amino Acids, Peptide Mimetics and Peptide Conjugates

Moree, Wilna J., Sears, Pamela, Kawashiro, Katsuhiro, Witte, Krista, Wong, Chi-Huey

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 363 KB

english, 1997

24

Chemical Development of NBI-75043. Use of a Flow Reactor to Circumvent a Batch-Limited Metal−Halogen Exchange Reaction

Gross, Timothy D., Chou, Shine, Bonneville, Daniel, Gross, Raymond S., Wang, Peng, Campopiano, Onorato, Ouellette, Michael A., Zook, Scott E., Reddy, Jayachandra P., Moree, Wilna J.

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 563 KB

english, 2008

25

Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia

Satheesh Babu Ravula, Jinghua Yu, Joe A. Tran, Melissa Arellano, Fabio C. Tucci, Wilna J. Moree, Bin-Feng Li, Robert E. Petroski, Jianyun Wen, Siobhan Malany, Samuel R.J. Hoare, Ajay Madan, Paul D. Cr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 872 KB

english, 2012

26

Microbial metabolic exchange in 3D

Watrous, Jeramie D, Phelan, Vanessa V, Hsu, Cheng-Chih, Moree, Wilna J, Duggan, Brendan M, Alexandrov, Theodore, Dorrestein, Pieter C

Journal:

The ISME Journal

Year:

2013

Language:

english

File:

PDF, 3.23 MB

english, 2013

27

The expanding role of H 1 antihistamines: a patent survey of selective and dual activity compounds 2005 – 2010

Beaton, Graham, Moree, Wilna J

Journal:

Expert Opinion on Therapeutic Patents

Year:

2010

Language:

english

File:

PDF, 820 KB

english, 2010

28

Imaging Mass Spectrometry of a Coral Microbe Interaction with Fungi

Wilna J. Moree, Jane Y. Yang, Xiling Zhao, Wei-Ting Liu…

Journal:

Journal of Chemical Ecology

Year:

2013

Language:

english

File:

PDF, 758 KB

english, 2013

29

Characterization of Novel Selective H 1 -Antihistamines for Clinical Evaluation in the Treatment of Insomnia

Moree, Wilna J., Li, Bin-Feng, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Gross, Raymond S., Tucci, Fabio, Marinkovic, Dragan, Zamani-Kord, Said, Malany, Siobhan, Bradbury, Margaret J., Hernandez, L

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 711 KB

english, 2009

30

Microbiota of Healthy Corals Are Active against Fungi in a Light-Dependent Manner

Moree, Wilna J., McConnell, Oliver J., Nguyen, Don D., Sanchez, Laura M., Yang, Yu-Liang, Zhao, Xiling, Liu, Wei-Ting, Boudreau, Paul D., Srinivasan, Jayashree, Atencio, Librada, Ballesteros, Javier,

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.08 MB

english, 2014

31

Solid-phase synthesis of O-phosphorothioylserine- and -threonine-containing peptides as well as of O-phosphoserine- and -threonine-containing peptides

De Bont, Dries B. A., Moree, Wilna J., Van Boom, Jacques H., Liskamp, Rob M. J.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 1.19 MB

english, 1993

32

MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus

Liu, Wei-Ting, Lamsa, Anne, Wong, Weng Ruh, Boudreau, Paul D, Kersten, Roland, Peng, Yao, Moree, Wilna J, Duggan, Brendan M, Moore, Bradley S, Gerwick, William H, Linington, Roger G, Pogliano, Kit, Do

Journal:

The Journal of Antibiotics

Year:

2014

Language:

english

File:

PDF, 1.79 MB

english, 2014

33

Homocarbonates as Substrates for the Enantioselective Enzymatic Protection of Amines

Orsat, Bernard, Alper, Phil B., Moree, Wilna, Mak, Ching-Pong, Wong, Chi-Huey

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 146 KB

english, 1996

34

Observations on different resin strategies for affinity purification mass spectrometry of a tagged protein

Mali, Sujina, Moree, Wilna J., Mitchell, Morgan, Widger, William, Bark, Steven J.

Journal:

Analytical Biochemistry

Year:

2016

Language:

english

File:

PDF, 591 KB

english, 2016

35

Solid support resins and affinity purification mass spectrometry

Havis, Spencer, Moree, Wilna J., Mali, Sujina, Bark, Steven J.

Journal:

Molecular BioSystems

Year:

2017

Language:

english

File:

PDF, 1015 KB

english, 2017

36

Formaldehyde scavengers function as novel antigen retrieval agents

Vollert, Craig T., Moree, Wilna J., Gregory, Steven, Bark, Steven J., Eriksen, Jason L.

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 597 KB

english, 2015

37

Engineered chymotrypsiN for mass-spectrometry based detection of protein glycosylation

Ramesh, Balakrishnan, Abnouf, Shaza, Mali, Sujina, Moree, Wilna J, Patil, Ujwal, Bark, Steven J, Varadarajan, Navin

Journal:

ACS Chemical Biology

Year:

2019

Language:

english

File:

PDF, 5.90 MB

english, 2019

38

Engineered chymotrypsiN for mass-spectrometry based detection of protein glycosylation

Ramesh, Balakrishnan, Abnouf, Shaza, Mali, Sujina, Moree, Wilna J, Patil, Ujwal, Bark, Steven J, Varadarajan, Navin

Journal:

ACS Chemical Biology

Year:

2019

File:

PDF, 5.90 MB

2019